follow up im at 2.4 and the appetite effect is stronger than i expected, normal
#retatrutide 2026-05-05
Tuesday63 messages15 participantstimes are UTC
Highlights from this day
- batch_bandit — morning resting HR, seated BP after 5 min, same cuff throughout 20:40
- first_vial_finn — this is the kind of thing i came here for 20:44
- elder_eu — daily, watch derived so treat the absolute values loosely 21:03
- VialBot — archive lookup: 5 heart-rate series logged in #retatrutide, mean reported rise +7 bpm, range +3 to +16. n is tiny, treat accordingly. 21:44
- first_vial_finn — range plus 3 to plus 16 is quite a range 21:45
is TRIUMPH the phase 3 programme
did the phase 2 result actually come in higher than the tirzepatide numbers
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unrelated but i said 8 months ago that my heart rate had settled and it has stayed settled since
logging rhr daily
no long term data
the half life supports weekly dosing and thats what ive done from the start
low and slow
anyone tracking blood pressure alongside the heart rate
nobody should read my log as a plan, im recording what i did and thats all it is
glucagon is the new bit
settled by month three
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research use only
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ok so low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
cant feel it honestly
*Janoshik not the other one
did the phase 2 plateau or was it still moving at the end
blood pressure stayed flat for me while heart rate moved, which i didnt expect
dumping my log because someone asked last month and i said id do it when i hit six months
morning resting HR, seated BP after 5 min, same cuff throughout
wk dose rHR BP note
0 - 56 118/74 baseline, 3 day avg
2 1mg 58 117/72
4 1mg 59 115/71
6 2mg 64 114/70 first noticeable week
8 2mg 66 112/68
10 2mg 65 113/69
12 3mg 71 110/67 held here
16 3mg 69 109/66
20 3mg 67 111/68
24 3mg 64 112/69 settled ~8 above baseline
this is the kind of thing i came here for
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clean log. the shape is the same as the trial mean, up during escalation then partial return while holding
and note you held at 12 weeks rather than pushing. thats the variable most logs in here are missing
i held because 71 scared me, not because i had a plan
the most common titration strategy in the archive
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mine is uglier. resting went 62 to 78 and stayed there for four months
daily, watch derived so treat the absolute values loosely
rhr-daily-6mo.csv
184 rows · 6 KB · not retained in the public archive
78 sitting there for four months is a different animal to a transient bump
yeah. i came off at month five
did it come back down after you stopped
to 64 within three weeks. so it was the drug, not me getting unfit
thats a useful natural experiment even though it sucked for you
im the outlier the other way, mine barely moved. plus 3 at most and i went to 6mg
which is why nobody can tell you what yours will do. the between person variation is enormous
is there anything that predicts it
nothing published that i trust. baseline fitness gets suggested a lot and @yara_yields blows a hole in that one
i am extremely unfit, for the record
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then that theory is dead too
i had to stop for a reason i would rather not put in a public archive, so leaving it out
[redacted at member request] · archive policy
no problem, thats what the redaction flag is for
who was collecting these, is there a spreadsheet
sort of. #archive-notes has the running index, five HR series and three with BP alongside
VendorInvestigate also has a write up on a couple of the batches involved, worth cross referencing which lot each log was on
good point. an HR log without a lot number is half a data point
archive lookup: 5 heart-rate series logged in #retatrutide, mean reported rise +7 bpm, range +3 to +16. n is tiny, treat accordingly.
range plus 3 to plus 16 is quite a range
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and thats the whole message of this conversation in one line
on the holding point — if id held at 6mg instead of pushing to 8 im not sure id have come off at all
thats been my read of a lot of the drop outs in here. it was the climb, not the compound
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan, i could be wrong
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i log resting heart rate every morning because of this and its the one number i actually watch
anyone compared their Janoshik purity across two different Homopeptide lots
anyone stayed at 1.7 for months rather than climbing
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
people insist on small steps because the side effects arrive faster than on the other two
GI was about the same as tirzepatide for me, the difference was how fast it arrived, from memory
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
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watching my heart rate
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whats the half life like, is it weekly the same way
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came off at 8 weeks because my resting rate stayed elevated and i didnt like it
people insist on small steps because the side effects arrive faster than on the other two
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