Janoshik came back 99.4 on one lot and 99 on the next from the same SWB, both fine
#retatrutide 2026-05-06
Wednesday48 messages8 participantstimes are UTC
Highlights from this day
- karl_fischer — there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists, thats one data point 06:38
- swab_dry_first — TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule 10:35
- deamidation — anyone logging resting heart rate on this 12:00
- deamidation — whats a sensible starting point, im seeing everything from 0.5 to 2 12:12
GI was about the same as tirzepatide for me, the difference was how fast it arrived
held mine ages
my resting heart rate is up about 7 bpm, did that settle for anyone
triple agonist yeah
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists, thats one data point
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buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely, ask me again in a month
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
while im here anyone tracking blood pressure alongside the heart rate
the half life supports weekly dosing and thats what ive done from the start
im at 2.5 and the appetite effect is stronger than i expected, normal
does the glucagon arm explain the heart rate or is that unrelated
held at 2 for 16 months and it never plateaued for me, which i cant explain, anyway
reconstituted the 2 vial to 10mg/ml specifically so i could take 0.5 without measuring crumbs
whats the half life like, is it weekly the same way
why does everyone insist on smaller steps here than on the other two
my resting rate went up 5 bpm in the first month and came back most of the way by month 13, your mileage will differ
glucagon is the new bit
nobody should read my log as a plan, im recording what i did and thats all it is
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
sat at 10 for 8 months rather than climbing and it kept working, so i never went up
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research use only
did the phase 2 plateau or was it still moving at the end
triple agonist meaning GLP-1, GIP and glucagon, have i got that right
is the GI worse than tirzepatide or about the same
watching my heart rate
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
unrelated but anyone gone above 0.25 and what changed
does the energy expenditure claim show up as anything you can feel
no long term data
appetite suppression at 12 was stronger than my tirzepatide experience at a comparable point
how do people square the research use only framing with logging their own use
the purity spread across lots worries me more than the molecule does
low and slow
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
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logging rhr daily
blood pressure stayed flat for me while heart rate moved, which i didnt expect
anyone compared their Medutest purity across two different KP lots
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
while im here stepping in 7.5 increments instead of doubling is the only thing i would change if i started again
quick one triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history, still working it out
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
anyone logging resting heart rate on this
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genuine question i log resting heart rate every morning because of this and its the one number i actually watch, ymmv
whats a sensible starting point, im seeing everything from 0.5 to 2
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ok so the heart rate thing is real enough that i mention it whenever someone asks about starting