held at 1 for 17 months and it never plateaued for me, which i cant explain, n of 1 obviously
#retatrutide 2026-06-17
Wednesday62 messages14 participantstimes are UTC
Highlights from this day
- u100_pat — blood pressure stayed flat for me while heart rate moved, which i didnt expect 22:14
- is_this_forever — nobody should read my log as a plan, im recording what i did and thats all it is 22:37
- is_this_forever — appetite suppression at 0.5 was stronger than my tirzepatide experience at a comparable point 22:39
came off at 8 weeks because my resting rate stayed elevated and i didnt like it
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
how long before people saw the first change at 1
the half life supports weekly dosing and thats what ive done from the start
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
*that should say weekly
anyone stayed at 0.5 for months rather than climbing
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual, ymmv
does the energy expenditure claim show up as anything you can feel
stepping in 2.5 increments instead of doubling is the only thing i would change if i started again
anyone gone above 0.25 and what changed
for the archive there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
the purity spread across lots worries me more than the molecule does, your mileage will differ
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
my resting rate went up 5 bpm in the first month and came back most of the way by month 7
the purity spread across lots worries me more than the molecule does
TRIUMPH is phase 3
GI was about the same as tirzepatide for me, the difference was how fast it arrived, i have it written down somewhere
back after 9 months, has anything actually been published since
cant feel it honestly
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phase 2 only
is there any long term safety data at all or is it phase 2 and hope
[edited]the honest position is this has less human evidence behind it than anything else discussed here
anyone tracking blood pressure alongside the heart rate
stopped for 21 months and restarted at half my old dose, the ramp was easier second time
settled by month three
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)VendorInvestigate came back 99.2 on one lot and 98.6 on the next from the same GGPeps, both fine
is the GI worse than tirzepatide or about the same
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the heart rate thing is real enough that i mention it whenever someone asks about starting
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
glucagon is the new bit
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mine went up too
held mine ages
low and slow
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i said 5 months ago that my heart rate had settled and it has stayed settled since
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reconstituted the 40 vial to 4mg/ml specifically so i could take 0.5 without measuring crumbs, i have it written down somewhere
people insist on small steps because the side effects arrive faster than on the other two, we shall see
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
no long term data
no idea whether the heart rate settles for everyone, mine did and one log isnt data
blood pressure stayed flat for me while heart rate moved, which i didnt expect
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smaller steps here
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me, ill dig out the number
VendorInvestigate came back 99.4 on one lot and 96.8 on the next from the same WXT, both fine
im at 12 and the appetite effect is stronger than i expected, normal
lost 25kg over 6 months at doses well under what the trials used
came off at 34 weeks because my resting rate stayed elevated and i didnt like it
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nobody should read my log as a plan, im recording what i did and thats all it is
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appetite suppression at 0.5 was stronger than my tirzepatide experience at a comparable point
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logging rhr daily
whats a sensible starting point, im seeing everything from 0.5 to 2
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Verification log updated: WWB — evidence added, status unchanged.
did the phase 2 result actually come in higher than the tirzepatide numbers
the purity spread across lots worries me more than the molecule does
*PeptideMeter not the other one
triple agonist yeah
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)sat at 2.4 for 6 months rather than climbing and it kept working, so i never went up
[edited]appetite suppression at 0.5 was stronger than my tirzepatide experience at a comparable point
watching my heart rate
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