STEP is several trials, so saying STEP said x is usually wrong without a number after it
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#semaglutide 2025-05-15
Thursday39 messages8 participantstimes are UTC
Highlights from this day
- reship_rita — STEP is several trials, so saying STEP said x is usually wrong without a number after it 19:27
- reship_rita — did anyone hold at 1 longer than four weeks before going up 21:17
- reship_rita — went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down 21:44
- meal_prep_mick — does anyone actually run a five week step instead of four 21:52
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
genuine question my dose day drifted from friday to sunday, does that reset anything
right so did anyone titrate slower than four weeks a step and how did that go
lost about 17kg on the low doses before i even got to 1, which surprised me
compounded and brand felt the same to me at 0.25, which is one person and nothing more
thats STEP 1
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*that should say weekly
2.4 is the ceiling
mine faded too
how did people handle the jump from 1 to 1.7
coming back to this my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
my 15 vial in 3ml gives 8mg/ml so 1.7 lands on 8 units, thats why i picked that volume, happy to be corrected
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genuine question vial units and pen clicks are different systems, mixing the two is how people end up wrong
vials not pens here
whats the actual licensed ceiling, i keep seeing different numbers
[edited]i dont think the plateau is a dose problem most of the time, but i cant prove that, i could be wrong
give it four weeks
slower worked better
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
steady state takes weeks
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure, happy to be corrected
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
is there a reason to hold at 1.7 rather than going to 2.4
medutest-report-c-4402.pdf
3 pages · 495 KB · not retained in the public archive
right so brand vs compounded, is there a difference people can actually feel
i held at 0.5 for 8 months and it was the best decision i made
the plateau hit me at 5 weeks and moved again about a month later without a dose change
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plateaus move
did the STEP 4 withdrawal arm show what i think it showed
same dose day
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
*that should say weekly
did anyone hold at 1 longer than four weeks before going up
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*week 26 not week 6
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
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i stayed on 1.7 for 23 months and never went to 2.4, appetite was already where i needed it, happy to be corrected
while im here im 17 months in at 12 and the appetite effect faded, is that a thing
does anyone actually run a five week step instead of four
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held at 0.5 and lost 41lb over 1 months, slower than the trials and fine by me
[edited]