#semaglutide 2025-06-25

mine faded too

i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication

not the same trial

SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial

did anyone hold at 12 longer than four weeks before going up

same dose day

my VendorInvestigate report on the QSC vial came back 98.1 against a certificate saying 99

went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down

lost about 29kg on the low doses before i even got to 1, which surprised me

STEP 1 ran to 68 weeks. thats the one everyone half remembers

went too fast once

if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule, i think

ok so the plateau hit me at 21 weeks and moved again about a month later without a dose change

moving my dose day by a day or two never did anything noticeable for me

held there too

my 5 vial in 2.5ml gives 2.5mg/ml so 0.25 lands on 12 units, thats why i picked that volume

does the seven day half life mean the last two days are weaker

the appetite effect faded for me around 5 months and going up fixed it for a while

anyone compared their 10 vial dosing against the pen increments

how long till steady state, ive read the half life is about a week

2.4 is the ceiling

Verification log updated: ERP — evidence added, status unchanged.

seven days ish

did anyone titrate slower than four weeks a step and how did that go

brand vs compounded, is there a difference people can actually feel

held at 0.25 and lost 26lb over 22 months, slower than the trials and fine by me

for the archive changed my mind on the four week rule, i think it depends entirely on how the current dose feels

the long half life flattens the trough more than people expect, i never felt a day seven dip

is 2.4 the top or do people go past it

plateaus move

sorry to jump in compounded and brand felt the same to me at 1, which is one person and nothing more

the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing

does the licensed ceiling for weight differ from the diabetes one

11 months at 2.4 and the honest summary is diminishing returns after the first half

how many weeks before you noticed anything at 15

thats STEP 1

half life is about a week so youre roughly four to five weeks to steady state on any new dose

slightly off topic but how did people handle the jump from 1 to 1.7

im at 10 and stuck, did anyone break a plateau without going up

went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step, ask me again in a month