is there a reason to hold at 1.7 rather than going to 2.4
#semaglutide 2025-07-05
Saturday65 messages13 participantstimes are UTC
Highlights from this day
- lipase_lore — im at 7.5 and stuck, did anyone break a plateau without going up 21:49
- declared_value — how long till steady state, ive read the half life is about a week changed my mind on the four week rule, i think it depends entirely on how the current dose feels 21:53
- first_month_fi — SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial 22:08
- karl_fischer — STEP is several trials, so saying STEP said x is usually wrong without a number after it 22:44
- meal_prep_mick — my Janoshik report on the QSC vial came back 97.4 against a certificate saying 98.1 23:15
held there too
does moving my dose day by two days matter with a seven day half life
anyone compared their 2 vial dosing against the pen increments
vials not pens here
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the long half life flattens the trough more than people expect, i never felt a day seven dip
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im at 7.5 and stuck, did anyone break a plateau without going up
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went too fast once
how long till steady state, ive read the half life is about a week
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
2.4 is the ceiling
i dont think the plateau is a dose problem most of the time, but i cant prove that
does the seven day half life mean the last two days are weaker
plateaus move
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seven days ish
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
same dose day
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
my 40 vial in 5ml gives 2mg/ml so 0.25 lands on 20 units, thats why i picked that volume
how many weeks before you noticed anything at 12
i held at 5 for 9 months and it was the best decision i made
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half life is about a week so youre roughly four to five weeks to steady state on any new dose
thats STEP 1
slower worked better
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whats the actual licensed ceiling, i keep seeing different numbers
was SURPASS-2 the one that ran to 68 weeks or am i mixing them up
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
SELECT wasnt weight
i held at 1 for 6 months and it was the best decision i made
while im here what did SELECT actually measure, i see it quoted for everything
mine faded too
not the same trial
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
ok so lost about 6kg on the low doses before i even got to 1, which surprised me, not advice obviously
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
how long did the first 43kg take for people at the low doses
moving my dose day by a day or two never did anything noticeable for me
STEP is several trials, so saying STEP said x is usually wrong without a number after it
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgcompounded and brand felt the same to me at 2, which is one person and nothing more
held at 12 and lost 33lb over 26 months, slower than the trials and fine by me
restarted after 5 months off at a low dose and the nausea arrived exactly like the first time
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
the appetite effect faded for me around 5 months and going up fixed it for a while, happy to be corrected
the plateau hit me at 15 weeks and moved again about a month later without a dose change
five week steps worked better for me than four, purely on how the second week felt
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is the plateau at 11 weeks normal or am i doing something wrong
steady state takes weeks
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
i stayed on 1.7 for 8 months and never went to 2.4, appetite was already where i needed it, ill dig out the number
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
lost about 45kg on the low doses before i even got to 1, which surprised me
unrelated but my dose day drifted from friday to sunday, does that reset anything
my Janoshik report on the QSC vial came back 97.4 against a certificate saying 98.1
does the licensed ceiling for weight differ from the diabetes one
sorry to jump in changed my mind on the four week rule, i think it depends entirely on how the current dose feels
compounded and brand felt the same to me at 12, which is one person and nothing more
did the STEP 4 withdrawal arm show what i think it showed
give it four weeks
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went too fast once
STEP 1 ran to 68 weeks. thats the one everyone half remembers, anyway
did anyone titrate slower than four weeks a step and how did that go
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
SELECT wasnt weight
€55 a month for compounded against what brand costs locally is why most people here use vials
anyone gone from 0.25 straight to 2.5 or is that too big a jump