SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
18 months at 2.4 and the honest summary is diminishing returns after the first half
#semaglutide 2025-12-05
Friday16 messages4 participantstimes are UTC
Highlights from this day
- logrotate — SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial 18 months at 2.4 and the honest summary is diminishing returns… 14:20
- logrotate — genuine question i stayed on 1.7 for 23 months and never went to 2.4, appetite was already where i needed it 14:31
- step_one_sian — the long half life flattens the trough more than people expect, i never felt a day seven dip 15:27
- truncation_tru — did the STEP 4 withdrawal arm show what i think it showed 15:28
- truncation_tru — im 18 months in at 5 and the appetite effect faded, is that a thing 15:36
does anyone actually run a five week step instead of four
genuine question i stayed on 1.7 for 23 months and never went to 2.4, appetite was already where i needed it
unrelated but was SELECT the one that ran to 68 weeks or am i mixing them up
SELECT wasnt weight
slower worked better
the appetite effect faded for me around 16 months and going up fixed it for a while
thats STEP 1
moving my dose day by a day or two never did anything noticeable for me
not the same trial
🧊15👀3
for the archive whats the actual licensed ceiling, i keep seeing different numbers
how did people handle the jump from 1 to 1.7
the long half life flattens the trough more than people expect, i never felt a day seven dip
im 18 months in at 5 and the appetite effect faded, is that a thing
[edited]fridge-temps.csv
237 rows · not retained in the public archive
my 30 vial in 2ml gives 2.5mg/ml so 2.4 lands on 15 units, thats why i picked that volume