same dose day
👀18
#semaglutide 2025-12-06
Saturday38 messages11 participantstimes are UTC
Highlights from this day
vial units and pen clicks are different systems, mixing the two is how people end up wrong
i stayed on 1.7 for 9 months and never went to 2.4, appetite was already where i needed it
💀1🤝9👍1
how long did the first 18kg take for people at the low doses
sorry to jump in compounded and brand felt the same to me at 2.5, which is one person and nothing more
unrelated but held at 5 and lost 25lb over 16 months, slower than the trials and fine by me
quick one i dont think the plateau is a dose problem most of the time, but i cant prove that
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
🙏2❤️9
restarted after 25 months off at a low dose and the nausea arrived exactly like the first time
the plateau hit me at 11 weeks and moved again about a month later without a dose change
STEP 1 ran to 68 weeks. thats the one everyone half remembers
follow up the appetite effect faded for me around 18 months and going up fixed it for a while
is the plateau usually appetite coming back or just the scale stopping
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
five week steps worked better for me than four, purely on how the second week felt
STEP 1 ran to 68 weeks. thats the one everyone half remembers
half life is about a week so youre roughly four to five weeks to steady state on any new dose
what did SELECT actually measure, i see it quoted for everything
held there too
how long till steady state, ive read the half life is about a week
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgthe trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
⚠️4
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
i held at 15 for 7 months and it was the best decision i made, n of 1 obviously
🤝10✅13📉10
19:08tenpence pinned a message to this channel
plateaus move
im 12 months in at 1 and the appetite effect faded, is that a thing
STEP is several trials, so saying STEP said x is usually wrong without a number after it
15 months at 2.4 and the honest summary is diminishing returns after the first half
did anyone titrate slower than four weeks a step and how did that go
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg📈6🔥8
give it four weeks
lot-log.csv
192 rows · not retained in the public archive
seven days ish
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgsteady state is the bit people skip, judging a new dose after eight days tells you almost nothing
vials not pens here
brand vs compounded, is there a difference people can actually feel
[edited]if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule, i think
😂1
SELECT wasnt weight
how many weeks before you noticed anything at 1.7
steady state takes weeks
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgmy VendorInvestigate report on the BCH vial came back 99.2 against a certificate saying 98.6