#semaglutide 2026-04-25

half life is about a week so youre roughly four to five weeks to steady state on any new dose
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step

9 months at 2.4 and the honest summary is diminishing returns after the first half

Channel stats, last 30 days: 23 messages from 18 members.

did anybody find a difference between SGN and pharmacy at the same 0.25

im 14 months in at 2.5 and the appetite effect faded, is that a thing

how long till steady state, ive read the half life is about a week

dose day is sunday for me only because thats when i remember, not because sunday matters

does the licensed ceiling for weight differ from the diabetes one

anyone gone from 7.5 straight to 1 or is that too big a jump

if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule

my PeptideMeter report on the TFC vial came back 98.1 against a certificate saying 98.6

STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping

steady state takes weeks

restarted after 21 months off at a low dose and the nausea arrived exactly like the first time

thats STEP 1

i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication

seven days ish

licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose, ymmv

right so did the STEP 4 withdrawal arm show what i think it showed

my 30 vial in 1ml gives 8mg/ml so 1.7 lands on 8 units, thats why i picked that volume

back after 25 months off, do i restart at 0.25 or somewhere higher

steady state is the bit people skip, judging a new dose after eight days tells you almost nothing

how many weeks before you noticed anything at 7.5

the long half life flattens the trough more than people expect, i never felt a day seven dip

im at 2.4 and stuck, did anyone break a plateau without going up

how long did the first 32kg take for people at the low doses

SELECT wasnt weight

my dose day drifted from friday to sunday, does that reset anything

held there too

for the archive my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
dose day is sunday for me only because thats when i remember, not because sunday matters

same dose day

was SELECT the one that ran to 68 weeks or am i mixing them up

changed my mind on the four week rule, i think it depends entirely on how the current dose feels

i stayed on 1.7 for 16 months and never went to 2.4, appetite was already where i needed it

lost about 6kg on the low doses before i even got to 1, which surprised me

plateaus move

New independent result logged — QYB, lot F-1330, purity 99.4% (Medutest).

SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial

slightly off topic but compounded and brand felt the same to me at 2.5, which is one person and nothing more, take that with a pinch of salt

not the same trial

give it four weeks

going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution

Inter-lab diff for lot F-1330: 98.1% vs 99%. Within expected range.

the plateau hit me at 20 weeks and moved again about a month later without a dose change

is there a reason to hold at 1.7 rather than going to 2.4
the appetite effect faded for me around 14 months and going up fixed it for a while

STEP 1 ran to 68 weeks. thats the one everyone half remembers

five week steps worked better for me than four, purely on how the second week felt, anyway

mine faded too

does the seven day half life mean the last two days are weaker