7.5 gang
#tirzepatide 2025-05-31
Saturday32 messages6 participantstimes are UTC
Highlights from this day
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
did anyone go past 15 and was there any point to it
vial-c-4402-front.png
900 × 1200 · 131 KB · not retained in the public archive
if youre coming off semaglutide the honest answer is start low and find out, theres no table
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
⚠️3💀1
did anyone find the GI easier than semaglutide at an equivalent effect
went back to semaglutide after 14 months because the cost difference mattered more than the GI
📈14
restarted at 2.5 after 25 months off and the first two doses reminded me why titration exists
no gap when i switched, took the last semaglutide dose and started this a week later
while im here does the GIP arm actually explain the easier nausea or is that hand waving
how long before the dual thing was noticeable to you
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does, i could be wrong
is 7.5 really the sweet spot or is that just channel folklore
👀11🧪18🎉3
amsterdam_aliquotlicensed top is 15 weekly, past that is not a licensed dose and nobody here can tell…
is the sweet spot argument about effect or about side effects
*Janoshik not the other one
titrate slow
the sweet spot thing is survivorship, the people it worked for stayed and said so
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
switched from 2.5 semaglutide and started at 2.5, took the slow route, never regretted it
is there a reason to titrate slower than the four week schedule
the 40 vial in 1.5ml gives 4mg/ml which puts 1 on 5 units, nice round numbers
switched last year
back after 1 months, do i restart at 2.5 or pick up near where i left off
🎉1
right so at 0.5 my appetite went completely and i dropped back a step, eating nothing isnt a win
amsterdam_aliquotif youre coming off semaglutide the honest answer is start low and find out, theres no…
genuine question is SURMOUNT-OSA the sleep apnoea one
📉9
update on the earlier thing whats the plateau pattern here, same as semaglutide or different
im at 5 and thinking about 0.25, did anyone gain anything from that step
changed my mind about needing 15, i was chasing a number rather than an outcome, i could be wrong
15 is the top
💀13🎉9
does the appetite effect feel different or just stronger
did going from 10 semaglutide to 5 of this feel like a step down for anyone
40 units of a 2.5 solution is a lot of volume and i check that one twice every single time
[edited]is the 40 vial the common one or do people use 5