went back to semaglutide after 12 months because the cost difference mattered more than the GI
#tirzepatide 2025-06-28
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ok so coming off semaglutide, is there a conversion or do i restart at 2.5
janoshik-e-2205.pdf
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the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
easier gi for me
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same plateau here
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
i argued the sweet spot was nonsense and then spent 26 months at 7.5 not needing more
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
genuine question $38 for a 40 vial is roughly what ive paid for the last year
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for the archive the switch felt like a step down at first and then caught up around week 31
anyone stopped at 10 and stayed there for months
at 10 my appetite went completely and i dropped back a step, eating nothing isnt a win
is there a reason to titrate slower than the four week schedule
how many weeks at 7.5 before you knew it was enough
back after 8 months, do i restart at 2.5 or pick up near where i left off
GIP plus GLP-1
there is no clean conversion between the two, anyone giving you a ratio is guessing, still working it out
the sweet spot thing is survivorship, the people it worked for stayed and said so
my Medutest result on a HJ vial came in at 98.1 which is why i keep buying from them
5 did nothing
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
Testing queue: 2 submissions open, 17 awaiting dispatch.
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switched from 12 semaglutide and started at 2.5, took the slow route, never regretted it
*VendorInvestigate not the other one
did anyone go past 15 and was there any point to it
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
*VendorInvestigate not the other one
genuine question SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
the 5 vial in 0.5ml gives 4mg/ml which puts 2.4 on 20 units, nice round numbers
15 is the top
checked the units twice
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start low anyway
10 was enough
titrate slow
if youre coming off semaglutide the honest answer is start low and find out, theres no table, n of 1 obviously
switched last year
folklore probably
glucagon_armswitched from 12 semaglutide and started at 2.5, took the slow route, never regretted it
while im here the two compounds arent interchangeable week for week even if the effect ends up similar
the trials titrated every four weeks to a target, most people here stop at whatever works
40 units of a 2.5 solution is a lot of volume and i check that one twice every single time
the 2.5 to 5 step was the roughest one for me and everything after was easier
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
12 did nothing extra over 10 for me and that still holds a year later, anyway
held 10 for 18 months and lost 15kg over that stretch, slow and boring and fine
genuine question restarted at 2.5 after 3 months off and the first two doses reminded me why titration exists, take that with a pinch of salt
no gap when i switched, took the last semaglutide dose and started this a week later, ask me again in a month
is the 15 vial the common one or do people use 30
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plateaued at 30 weeks the same way i did on semaglutide, so i doubt its compound specific