is the sweet spot argument about effect or about side effects
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#tirzepatide 2025-07-31
Thursday44 messages8 participantstimes are UTC
Highlights from this day
anyone got a 8 recon they like for the 5 vials
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
is 7.5 really the sweet spot or is that just channel folklore
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
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at 1 my appetite is gone entirely, did anyone go down rather than up
*Janoshik not the other one
did going from 7.5 semaglutide to 5 of this feel like a step down for anyone
the trials titrated every four weeks to a target, most people here stop at whatever works
titrate slow
the sweet spot thing is survivorship, the people it worked for stayed and said so
*Janoshik not the other one
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
switched last year
12 did nothing extra over 10 for me and that still holds a year later
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checked the units twice
i sat at 7.5 for 25 months and never needed more, which is where the folklore comes from
Assay note: GGPeps lot D-0718 reported at 99.4% of label content.
at 7.5 my appetite went completely and i dropped back a step, eating nothing isnt a win
coming off semaglutide, is there a conversion or do i restart at 2.5
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anyone stopped at 10 and stayed there for months
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5 did nothing
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
whats the top licensed dose, 15 or does it go higher
at 15 the GI came back for me, so my easier profile claim only applies below that, we shall see
i sat at 7.5 for 4 months and never needed more, which is where the folklore comes from
does the GIP arm actually explain the easier nausea or is that hand waving
right so is SURMOUNT-OSA the sleep apnoea one
no gap when i switched, took the last semaglutide dose and started this a week later
the 20 vial in 3ml gives 8mg/ml which puts 0.5 on 15 units, nice round numbers
whats the plateau pattern here, same as semaglutide or different
the switch felt like a step down at first and then caught up around week 2
does switching from semaglutide need a gap or do you just start
15 is the top
im at 1 and thinking about 15, did anyone gain anything from that step
the switch felt like a step down at first and then caught up around week 3
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update on the earlier thing the two compounds arent interchangeable week for week even if the effect ends up similar
went back to semaglutide after 19 months because the cost difference mattered more than the GI, thats one data point
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
anyone tracked whether the GI difference held at the top doses
how many weeks at 7.5 before you knew it was enough
there is no clean conversion between the two, anyone giving you a ratio is guessing
folklore probably
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changed my mind about needing 15, i was chasing a number rather than an outcome
is the 20 vial the common one or do people use 10
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i log everything and my appetite curve looks flatter across the week than my semaglutide log did
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the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact