did anybody switch back to semaglutide after trying this
[edited]#tirzepatide 2025-12-07
Sunday24 messages5 participantstimes are UTC
Highlights from this day
- tarpit_tam — the sweet spot argument is really about effect per side effect, not a magic number, we shall see 18:52
- ferrous_ash — 12 did nothing extra over 10 for me and that still holds a year later i went to 15 and came back to 10, more suppression wasnt more useful for me 19:07
- ollie_orders — switched from 2.5 semaglutide and started at 2.5, took the slow route, never regretted it 19:34
folklore probably
no gap when i switched, took the last semaglutide dose and started this a week later
the 40 vial in 2.5ml gives 2.5mg/ml which puts 0.25 on 20 units, nice round numbers
the sweet spot argument is really about effect per side effect, not a magic number, we shall see
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
5 did nothing
went back to semaglutide after 24 months because the cost difference mattered more than the GI
no clean conversion
the GI difference held for me right up to 15, which isnt what a couple of people here found
does the GIP arm actually explain the easier nausea or is that hand waving
12 did nothing extra over 10 for me and that still holds a year later
i went to 15 and came back to 10, more suppression wasnt more useful for me
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted, ill dig out the number
switched from 2.5 semaglutide and started at 2.5, took the slow route, never regretted it
😂18📉12🤝2
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does, i think
checked the units twice
👍3🧪1📉8
is the sweet spot argument about effect or about side effects
easier gi for me
held 10 for 26 months and lost 24kg over that stretch, slow and boring and fine
$38 for a 30 vial is roughly what ive paid for the last year
10 was enough
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
if youre coming off semaglutide the honest answer is start low and find out, theres no table
i sat at 7.5 for 3 months and never needed more, which is where the folklore comes from