at 15 the GI came back for me, so my easier profile claim only applies below that
#tirzepatide 2025-12-08
Monday14 messages4 participantstimes are UTC
Highlights from this day
- tam_logs — SURMOUNT-1 versus SURPASS-2, which one was the weight trial 23:30
- HPLC_Hank — the two compounds arent interchangeable week for week even if the effect ends up similar 23:43
- HPLC_Hank — the sweet spot argument is really about effect per side effect, not a magic number 23:44
- HPLC_Hank — does switching from semaglutide need a gap or do you just start 23:52
anyone tracked whether the GI difference held at the top doses
no clean conversion
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
plateaued at 12 weeks the same way i did on semaglutide, so i doubt its compound specific
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
❤️13😂6
switched last year
coming back to this there is no clean conversion between the two, anyone giving you a ratio is guessing, anyway
no gap when i switched, took the last semaglutide dose and started this a week later, not advice obviously
[edited]at 10 my appetite is gone entirely, did anyone go down rather than up
the two compounds arent interchangeable week for week even if the effect ends up similar
🤝1
the sweet spot argument is really about effect per side effect, not a magic number
GIP plus GLP-1
does switching from semaglutide need a gap or do you just start
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)