the plateau hit me at 11 weeks and moved again about a month later without a dose change
#semaglutide 2026-03-18
Wednesday73 messages14 participantstimes are UTC
Highlights from this day
- new_here_nat — my PeptideMeter report on the QYB vial came back 98.1 against a certificate saying 96.8 14:42
- customs_owl — STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping 16:19
- new_here_nat — i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, i have it written down somewhere 16:26
- VialBot — Testing queue: 7 submissions open, 40 awaiting dispatch. 17:45
- taper_tess — STEP is several trials, so saying STEP said x is usually wrong without a number after it 18:27
my PeptideMeter report on the QYB vial came back 98.1 against a certificate saying 96.8
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgwhat did SELECT actually measure, i see it quoted for everything
does anyone actually run a five week step instead of four
went too fast once
2.4 is the ceiling
same dose day
lost about 42kg on the low doses before i even got to 1, which surprised me
anyone compared their 10 vial dosing against the pen increments
*PeptideMeter not the other one
i held at 0.5 for 3 months and it was the best decision i made
not the same trial
plateaus move
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quick one moving my dose day by a day or two never did anything noticeable for me
give it four weeks
is 2.4 the top or do people go past it
did anyone titrate slower than four weeks a step and how did that go
half life is about a week so youre roughly four to five weeks to steady state on any new dose
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
SELECT wasnt weight
is the plateau usually appetite coming back or just the scale stopping
held at 0.25 and lost 79lb over 15 months, slower than the trials and fine by me
im 19 months in at 2.4 and the appetite effect faded, is that a thing
thats STEP 1
[edited]STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
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i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, i have it written down somewhere
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how long till steady state, ive read the half life is about a week
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*Medutest not the other one
restarted after 11 months off at a low dose and the nausea arrived exactly like the first time
half life is about a week so youre roughly four to five weeks to steady state on any new dose
held there too
was SURMOUNT-1 the one that ran to 68 weeks or am i mixing them up
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licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
i stayed on 1.7 for 13 months and never went to 2.4, appetite was already where i needed it, we shall see
my 10 vial in 1.5ml gives 4mg/ml so 15 lands on 40 units, thats why i picked that volume
4 months at 2.4 and the honest summary is diminishing returns after the first half, ill dig out the number
steady state takes weeks
did the STEP 4 withdrawal arm show what i think it showed
STEP 1 ran to 68 weeks. thats the one everyone half remembers
slower worked better
the appetite effect faded for me around 6 months and going up fixed it for a while
Reminder set. I will post here in 5 days.
mine faded too
im at 1 and stuck, did anyone break a plateau without going up
[edited]Testing queue: 7 submissions open, 40 awaiting dispatch.
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$94 a month for compounded against what brand costs locally is why most people here use vials
is the plateau at 24 weeks normal or am i doing something wrong
*week 24 not week 8
right so went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
Archive lookup: LC_MS_Lena first appears in this channel on 2025-08-09.
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Purity check: no report on file for lot SG-1177. Nothing logged either way.
brand vs compounded, is there a difference people can actually feel
STEP is several trials, so saying STEP said x is usually wrong without a number after it
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changed my mind on the four week rule, i think it depends entirely on how the current dose feels
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
is there a reason to hold at 1.7 rather than going to 2.4
[edited]does the licensed ceiling for weight differ from the diabetes one
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
thats STEP 1
vial units and pen clicks are different systems, mixing the two is how people end up wrong
does the seven day half life mean the last two days are weaker
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
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compounded and brand felt the same to me at 2.4, which is one person and nothing more
the plateau hit me at 20 weeks and moved again about a month later without a dose change
*Medutest not the other one
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
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steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
the long half life flattens the trough more than people expect, i never felt a day seven dip
my dose day drifted from friday to sunday, does that reset anything
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
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plateaus move
i held at 15 for 3 months and it was the best decision i made