Fortnightly digest · 2024-06-17 → 2024-06-30
resting heart rate logs, because the glucagon arm is not free
The triple agonist channel had been drifting toward enthusiasm and this fortnight pulled it back. Several members posted resting heart rate data from wearables showing a rise they had not connected to anything, and the channel settled on its standing position: low, slow, log daily, and be honest that a Phase 2 result is not a safety record.
914messages
51day logs
3channels noted
5notes
What happened
- The retatrutide Phase 2 result in NEJM 2023 was read properly, including the parts about heart rate, rather than quoted for its weight-loss figure alone.
- Four members posted resting heart rate traces from before and after starting, and three of them showed a rise they had attributed to poor sleep.
- There is no long-term safety data on retatrutide and the channel said so twice this fortnight without anybody arguing.
- A newcomer asked to start at a mid-range dose because a Phase 2 arm used it and got a patient explanation of what a monitored trial provides that a bedroom does not.
- The research-use-only status was restated in chat voice rather than legalese, which is the only register that ever lands.
Channels this fortnight
#retatrutideRetatrutide. Triple agonist. Research use only. No long-term safety data.4 logs · 82 msgs#side-effectsNausea, constipation, the month-four shed, and when to stop reading chat and see somebody.10 logs · 178 msgs#dosing-titrationLadders, holds, dose days. Escalate on symptoms, not on the calendar.6 logs · 140 msgs
Most-reacted messages in this fortnight
Pulled from the logs, not hand-picked. Each links to the exact message.
gip_glp_gil40 units of a 8 solution is a lot of volume and i check that one twice every single time41 reactions · #tirzepatide · 2024-06-20peak_splitwe refresh on new evidence, not on a clock. an old verification with no recent results says so on the entry, thats just me39 reactions · #vendor-verification · 2024-06-17lean_mass_lexask for a cold pack34 reactions · #vendor-talk · 2024-06-21tail_factorweigh it first33 reactions · #reconstitution · 2024-06-23septum_salroughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose31 reactions · #oral-glp1 · 2024-06-22seven_five_sweetwhat is everyone drinking now that alcohol has stopped being fun31 reactions · #off-topic · 2024-06-29cold_chain_cmdrthats not great28 reactions · #test-results · 2024-06-25two_ml_twogood bp move28 reactions · #wins · 2024-06-30
Busiest logs in this fortnight
#side-effects · 2024-06-23it got better for me39 msgs#side-effects · 2024-06-29coming back to this sulphur burps. is there anything at all that helps38 msgs#dosing-titration · 2024-06-24i drifted from sunday to wednesday over a year and only noticed when i checked the log34 msgs#wins · 2024-06-30thats brilliant34 msgs#reconstitution · 2024-06-23my vial pulled the water in on its own, is that the vacuum or did i do something32 msgs#retatrutide · 2024-06-26for the archive there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists32 msgs#test-results · 2024-06-24post the lot, the purchase month, the lab, the number, and what you were expecting. that makes it useful…30 msgs#tirzepatide · 2024-06-20the trials titrated every four weeks to a target, most people here stop at whatever works29 msgs#dosing-titration · 2024-06-29is week 24 too early to be thinking about the next step29 msgs#side-effects · 2024-06-17water first, then fibre, then magnesium, then a softener, then a pharmacist. in that order28 msgs#dosing-titration · 2024-06-20half life is a week28 msgs#dosing-titration · 2024-06-23came down, no regrets28 msgs