Topic
Retatrutide
Triple GIP/GLP-1/glucagon agonism, the Phase 2 result, the resting heart rate signal, and the room’s standing position that there is no long-term safety data.
162messages tagged
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2024-02first seen
2026-06last seen
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slow.taperi jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat#dosing-titration · 2024-02-15cold_chain_cmdrdid the phase 2 result actually come in higher than the tirzepatide numbers#retatrutide · 2024-04-23a1c_lagslightly off topic but i log resting heart rate every morning because of this and its the one number i actually watch, i have…#retatrutide · 2024-05-19two_four_ceilingcoming back to this i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind#retatrutide · 2024-07-01pinch_not_stretchis there any long term safety data at all or is it phase 2 and hope#retatrutide · 2024-07-07surpass_twoanyone compared their PeptideMeter purity across two different QST lots#retatrutide · 2024-07-19triple_ag_tomcant feel it honestly#retatrutide · 2024-08-11u100_patis the GI worse than tirzepatide or about the same#retatrutide · 2024-08-27apob_over_ldlphase 2 was still trending at the end which is why the phase 3 readout matters more than usual#retatrutide · 2024-08-29logrotatephase 2 doses are published and theyre not far off what people here run, coincidence rather than plan#retatrutide · 2024-10-02area_percentwhats a sensible maintenance dose after a year at treatment dose#dosing-titration · 2024-10-12pooled_sampletriple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history#retatrutide · 2024-10-17dublin_dosego slower#dosing-titration · 2024-10-17step_one_sianwhy does everyone insist on smaller steps here than on the other two#retatrutide · 2024-10-19blank_slate_boso tirz is two receptors and reta is three. whats the third one doing#retatrutide · 2024-10-19peak_splitfor retatrutide specifically the published phase 2 was a weight and safety trial, not a calorimetry study#retatrutide · 2024-10-19vial_ledgerRetatrutide phase 2 — GIP / GLP-1 / glucagon triple agonist in obesity#retatrutide · 2024-10-19blank_slate_bocoming back to your burn question answer — is there anything measuring resting metabolic rate on reta in humans yet#retatrutide · 2024-10-19HPLC_Hankcode block#vendor-verification · 2024-10-27tenpencecode block#vendor-verification · 2024-10-27lot_number_loui am going to defend myself and say 96.4 on retatrutide is harder than 99 on semaglutide. longer chain, more places to go wrong#vendor-verification · 2024-10-27relabel_watchis the phase 2 dosing anywhere near what people here run#retatrutide · 2024-11-03lyophile_livpeople insist on small steps because the side effects arrive faster than on the other two#retatrutide · 2024-11-09oasis_olawatching my heart rate#retatrutide · 2024-11-11batch_banditis the GI worse than tirzepatide or about the same#retatrutide · 2024-11-12triple_ag_tomphase 2 doses are published and theyre not far off what people here run, coincidence rather than plan#retatrutide · 2024-11-23pharmac_penis TRIUMPH the phase 3 programme#retatrutide · 2024-11-25warsaw_vialresearch use only is on every vial and i treat it as exactly that, nobody here is prescribing#retatrutide · 2024-12-01split_dose_samphase 2 doses are published and theyre not far off what people here run, coincidence rather than plan#retatrutide · 2024-12-01triple_ag_tomsplit dosing has no trial behind it. people here do it and report on it, thats all#dosing-titration · 2025-01-05spare_vialno idea whether the heart rate settles for everyone, mine did and one log isnt data#retatrutide · 2025-01-06pinch_not_stretchis there any long term safety data at all or is it phase 2 and hope#retatrutide · 2025-01-15pinch_not_stretchanyone stayed at 5 for months rather than climbing#retatrutide · 2025-01-15pbs_pipphase 2 only#retatrutide · 2025-01-19pbs_pipglucagon is the new bit#retatrutide · 2025-01-19cold_start_cyhas anyone gone up and then straight back down and been glad they tried#dosing-titration · 2025-01-19seven_five_sweetpeople insist on small steps because the side effects arrive faster than on the other two#retatrutide · 2025-01-22subq_syresearch use only#retatrutide · 2025-01-24thirty_min_waitnobody should read my log as a plan, im recording what i did and thats all it is#retatrutide · 2025-02-06still_here_2024i log resting heart rate every morning because of this and its the one number i actually watch#retatrutide · 2025-02-08slow.tapern of 1#dosing-titration · 2025-02-09maintenance_moreconstituted the 30 vial to 10mg/ml specifically so i could take 2.4 without measuring crumbs#retatrutide · 2025-02-15split_dose_samstepping in 1.7 increments instead of doubling is the only thing i would change if i started again#retatrutide · 2025-02-18madrid_mgthe half life supports weekly dosing and thats what ive done from the start, thats one data point#retatrutide · 2025-03-13two_three_liftsglucagon is the new bit#retatrutide · 2025-03-13LC_MS_Lenatriple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history#retatrutide · 2025-03-19ferrous_ashdid the phase 2 result actually come in higher than the tirzepatide numbers#retatrutide · 2025-03-19dose_day_drifti was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind#retatrutide · 2025-03-22septum_salresearch use only#retatrutide · 2025-03-25deadspacedoes the glucagon arm explain the heart rate or is that unrelated#retatrutide · 2025-04-03gip_glp_gili was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind, from memory i was…#retatrutide · 2025-04-04homa_ir_hugosettled by month three#retatrutide · 2025-04-08void_volumemine went up too#retatrutide · 2025-04-13lot_number_loustopped for 3 months and restarted at half my old dose, the ramp was easier second time#retatrutide · 2025-04-21spreadsheet_stuthe heart rate thing is real enough that i mention it whenever someone asks about starting#retatrutide · 2025-04-22dexa_or_biacant feel it honestly#retatrutide · 2025-04-24still_here_2024anyone stayed at 15 for months rather than climbing#retatrutide · 2025-04-25eighteen_monthsgenuine question GI was about the same as tirzepatide for me, the difference was how fast it arrived#retatrutide · 2025-04-26turnaround_tamdoes the energy expenditure claim show up as anything you can feel#retatrutide · 2025-05-24hair_month_fourwhats the smallest step anyone has managed between doses#dosing-titration · 2025-05-24