Topic
Oral GLP-1s
Page 4 of 13 — Oral semaglutide with SNAC, roughly one percent bioavailability, the fasting and plain-water rules, and the non-peptide orals…
Messages — page 4 of 13
oli_oralsSNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2025-07-21halifax_hplcchanged my mind on the plain water rule after reading how SNAC works, its not a formality#oral-glp1 · 2025-07-21tokyo_taperthe non peptide orals are the interesting part of this channel now, not oral semaglutide, thats just me#oral-glp1 · 2025-07-23baseline_driftSNAC raises the local pH and protects it long enough to cross, thats its whole job plain water only, about half a glass, then…#oral-glp1 · 2025-07-23glasgow_vialgenuine question orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ i do 6am…#oral-glp1 · 2025-07-23rotate_the_sitewhy is the oral dose in mg so much bigger than the injectable one#oral-glp1 · 2025-07-23taper_or_notthe non peptide orals are the interesting part of this channel now, not oral semaglutide#oral-glp1 · 2025-07-27two_three_liftsis orforglipron a peptide at all#oral-glp1 · 2025-07-27two_three_liftsSNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2025-07-27taper_or_notis the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2025-07-27apnoea_down_twoPIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses#oral-glp1 · 2025-08-02fasting_insulinchanged my mind on the plain water rule after reading how SNAC works, its not a formality coffee is not plain water. i tried…#oral-glp1 · 2025-08-02no_chargebackis the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2025-08-07underfill_umaSNAC does the work#oral-glp1 · 2025-08-07electrolyte_eliSNAC does the work#oral-glp1 · 2025-08-08assay_low_aldoes SNAC do anything other than get it through the stomach#oral-glp1 · 2025-08-08tarpit_tamis the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2025-08-08tarpit_tamPIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses#oral-glp1 · 2025-08-08stack_scepticis orforglipron a peptide at all#oral-glp1 · 2025-08-08same_chromatoSNAC does the work#oral-glp1 · 2025-08-09taper_tesschanged my mind on the plain water rule after reading how SNAC works, its not a formality#oral-glp1 · 2025-08-09vik_verifiesquick one the non peptide orals are the interesting part of this channel now, not oral semaglutide#oral-glp1 · 2025-08-09pinch_not_stretchthe non peptide orals are the interesting part of this channel now, not oral semaglutide roughly one percent gets absorbed,…#oral-glp1 · 2025-08-10ferritin_fayPIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses, i could be wrong#oral-glp1 · 2025-08-13oli_oralsorforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ, anyway#oral-glp1 · 2025-08-14oli_oralsfor the archive does SNAC do anything other than get it through the stomach#oral-glp1 · 2025-08-14half_life_halSNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2025-08-17vik_verifiesslightly off topic but the non peptide orals are the interesting part of this channel now, not oral semaglutide, ask me again…#oral-glp1 · 2025-08-17area_percentchanged my mind on the plain water rule after reading how SNAC works, its not a formality, thats one data point#oral-glp1 · 2025-08-18area_percentorforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ, not advice obviously#oral-glp1 · 2025-08-18month_six_medoes SNAC do anything other than get it through the stomach#oral-glp1 · 2025-08-23endotoxin_edPIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses#oral-glp1 · 2025-08-23protein_floorthe non peptide orals are the interesting part of this channel now, not oral semaglutide#oral-glp1 · 2025-08-23mcg_not_mgwent back to injecting#oral-glp1 · 2025-08-23mcg_not_mgis orforglipron a peptide at all#oral-glp1 · 2025-08-23sharps_bin_sidorforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ#oral-glp1 · 2025-08-25ollie_ordersSNAC does the work#oral-glp1 · 2025-08-25tesa_tessswitched from injectable to oral, lost some of the effect, switched back after 18 months, someone check my working#oral-glp1 · 2025-08-26thirty_min_waitSNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2025-08-27orfor_watchSNAC does the work#oral-glp1 · 2025-08-27pbs_pipis the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2025-08-27triple_ag_tomSNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2025-08-30bac_water_billsplitting a dose made the absorption problem worse rather than better in my own log#oral-glp1 · 2025-08-31sgp_subqdoes SNAC do anything other than get it through the stomach#oral-glp1 · 2025-08-31thirty_min_waitis orforglipron a peptide at all#oral-glp1 · 2025-08-31bac_water_billorforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ#oral-glp1 · 2025-08-31identity_shiftPIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses#oral-glp1 · 2025-08-31sgp_subqSNAC does the work#oral-glp1 · 2025-08-31secretagogue_syis the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2025-08-31vialkeeperorforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ, ymmv#oral-glp1 · 2025-09-01no_appetite_niais orforglipron a peptide at all#oral-glp1 · 2025-09-01vialkeeperdoes SNAC do anything other than get it through the stomach#oral-glp1 · 2025-09-01orfor_watchSNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2025-09-01no_appetite_niais the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2025-09-01hr_log_hattieSNAC does the work#oral-glp1 · 2025-09-01hr_log_hattiePIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses, not advice obviously#oral-glp1 · 2025-09-01hr_log_hattiethe non peptide orals are the interesting part of this channel now, not oral semaglutide#oral-glp1 · 2025-09-01apnoea_down_twoSNAC does the work#oral-glp1 · 2025-09-07apnoea_down_twoorforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ, take that with a pinch of…#oral-glp1 · 2025-09-07first_and_last_fouris the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2025-09-10