Topic
Oral GLP-1s
Oral semaglutide with SNAC, roughly one percent bioavailability, the fasting and plain-water rules, and the non-peptide orals that do not carry them.
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2024-06first seen
2026-06last seen
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split_dose_samSNAC raises the local pH and protects it long enough to cross, thats its whole job, someone check my working#oral-glp1 · 2024-06-01deadspaceis the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2024-06-01night_pincoming back to this PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses#oral-glp1 · 2024-06-22karl_fischeris the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2024-06-22night_pinhow much water exactly, is it a small sip or half a glass#oral-glp1 · 2024-06-22split_dose_samSNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2024-07-06per_mg_peteis orforglipron a peptide at all#oral-glp1 · 2024-10-03protein_flooris the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2024-10-03underfill_umaPIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses#oral-glp1 · 2024-10-03comment_fatigueSNAC does the work#oral-glp1 · 2024-10-26snac_and_wateris orforglipron a peptide at all#oral-glp1 · 2024-11-09first_and_last_fouris the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2024-11-09electrolyte_elitook mine with breakfast once by accident and that week was a write off#oral-glp1 · 2024-11-09acetate_ashis orforglipron a peptide at all#oral-glp1 · 2024-11-18acetate_ashchanged my mind on the plain water rule after reading how SNAC works, its not a formality#oral-glp1 · 2024-11-18deadspaceis the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2024-12-07deadspaceset a timer#oral-glp1 · 2024-12-07group_buy_gwenunrelated but changed my mind on the plain water rule after reading how SNAC works, its not a formality#oral-glp1 · 2024-12-07septum_salchanged my mind on the plain water rule after reading how SNAC works, its not a formality#oral-glp1 · 2024-12-11verify_or_dontis the non peptide thing why orforglipron doesnt need the fasting rules the inconsistency is mostly technique and admitting…#oral-glp1 · 2024-12-11egfr_edthe non peptide orals are the interesting part of this channel now, not oral semaglutide, we shall see#oral-glp1 · 2024-12-14vienna_vialdoes SNAC do anything other than get it through the stomach#oral-glp1 · 2024-12-16vienna_vialdoes SNAC do anything other than get it through the stomach#oral-glp1 · 2024-12-16karl_fischerchanged my mind on the plain water rule after reading how SNAC works, its not a formality#oral-glp1 · 2025-01-10drawup_deeis the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2025-01-10relabel_watchSNAC does the work#oral-glp1 · 2025-01-22split_dose_samdoes the 30 minutes start from swallowing or from the water#oral-glp1 · 2025-01-22triple_ag_tomchanged my mind on the plain water rule after reading how SNAC works, its not a formality, still working it out#oral-glp1 · 2025-01-22ring_size_downdoes SNAC do anything other than get it through the stomach#oral-glp1 · 2025-01-26hydrate_hanathe non peptide orals are the interesting part of this channel now, not oral semaglutide#oral-glp1 · 2025-01-26reship_ritais orforglipron a peptide at all#oral-glp1 · 2025-01-26lipase_loreis the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2025-01-26first_and_last_fourchanged my mind on the plain water rule after reading how SNAC works, its not a formality#oral-glp1 · 2025-01-28factory_direct_fiis the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2025-01-28factory_direct_fidoes SNAC do anything other than get it through the stomach#oral-glp1 · 2025-01-28oasis_olaSNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2025-01-28month_six_meok so PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses#oral-glp1 · 2025-01-29month_six_methe oral disappointed me on the mornings i couldnt manage 30 minutes fasted, which was most of them#oral-glp1 · 2025-01-29snac_and_waterslightly off topic but SNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2025-02-01oasis_olaorforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ#oral-glp1 · 2025-02-01cold_start_cyis the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2025-02-01thirty_min_waitorforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ, happy to be corrected#oral-glp1 · 2025-02-02baseline_driftSNAC does the work#oral-glp1 · 2025-02-02batch_banditok so PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses lost 25kg over 1 months on…#oral-glp1 · 2025-02-02typosquat_tayfollow up is orforglipron a peptide at all plain water only, about half a glass, then nothing for 30 minutes. i follow it…#oral-glp1 · 2025-02-02batch_banditdoes SNAC do anything other than get it through the stomach#oral-glp1 · 2025-02-02gall_bladder_gavquick one the non peptide orals are the interesting part of this channel now, not oral semaglutide#oral-glp1 · 2025-02-02factory_direct_fiSNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2025-02-02dublin_dosedoes SNAC do anything other than get it through the stomach#oral-glp1 · 2025-02-08vial_ledgerSNAC raises the local pH and protects it long enough to cross, thats its whole job, thats just me#oral-glp1 · 2025-02-11acetate_ashorforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ#oral-glp1 · 2025-02-11verify_or_dontchanged my mind on the plain water rule after reading how SNAC works, its not a formality#oral-glp1 · 2025-02-11lyophile_livSNAC does the work#oral-glp1 · 2025-02-11reta_resting_hris orforglipron a peptide at all#oral-glp1 · 2025-02-18evidence_or_notSNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2025-02-19never_for_saleis orforglipron a peptide at all#oral-glp1 · 2025-02-21never_for_saledoes SNAC do anything other than get it through the stomach#oral-glp1 · 2025-02-21egfr_edPIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses, thats one data point#oral-glp1 · 2025-02-21egfr_edorforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ#oral-glp1 · 2025-02-21egfr_edis the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2025-02-21