Topic
Oral GLP-1s
Page 3 of 13 — Oral semaglutide with SNAC, roughly one percent bioavailability, the fasting and plain-water rules, and the non-peptide orals…
Messages — page 3 of 13
nordic_price_nilsSNAC does the work#oral-glp1 · 2025-05-10tail_factorOASIS 1 — oral semaglutide 50 mg in adults with overweight or obesity#oral-glp1 · 2025-05-10tail_factorthe pharmacokinetic variability for oral sema is substantially wider than for the injection. thats well described#oral-glp1 · 2025-05-10triumph_watchquick one does SNAC do anything other than get it through the stomach#oral-glp1 · 2025-05-11shame_and_medsis orforglipron a peptide at all#oral-glp1 · 2025-05-16warsaw_vialfor the archive absorption is the variable, not the molecule. same tablet, different morning, different result#oral-glp1 · 2025-05-16meal_prep_mickchanged my mind on the plain water rule after reading how SNAC works, its not a formality#oral-glp1 · 2025-05-24identity_shiftPIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses#oral-glp1 · 2025-05-25oasis_oladoes SNAC do anything other than get it through the stomach#oral-glp1 · 2025-05-25bp_down_bexSNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2025-05-25lot_number_louthe non peptide orals are the interesting part of this channel now, not oral semaglutide#oral-glp1 · 2025-05-25bp_down_bexorforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ#oral-glp1 · 2025-05-25net_peptideSNAC does the work#oral-glp1 · 2025-05-25bench_notesSNAC does the work#oral-glp1 · 2025-05-29first_month_fichanged my mind on the plain water rule after reading how SNAC works, its not a formality, ill dig out the number#oral-glp1 · 2025-05-29fasting_insulindoes SNAC do anything other than get it through the stomach#oral-glp1 · 2025-05-29appetite_backSNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2025-05-31appetite_backtook 22 weeks before i saw anything on oral, roughly twice what the injection took me#oral-glp1 · 2025-05-31quiet_head_qidoes SNAC do anything other than get it through the stomach#oral-glp1 · 2025-06-15quiet_head_qiPIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses, anyway#oral-glp1 · 2025-06-15assay_low_alwent back to injecting#oral-glp1 · 2025-06-15electrolyte_eliis the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2025-06-19snac_and_wateris the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2025-06-26oasis_olathe non peptide orals are the interesting part of this channel now, not oral semaglutide#oral-glp1 · 2025-06-26oasis_olathe non peptide orals are the interesting part of this channel now, not oral semaglutide#oral-glp1 · 2025-06-26rotterdam_recondoes SNAC do anything other than get it through the stomach#oral-glp1 · 2025-06-26mhra_unlicensedfollow up is the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2025-06-27cat_on_the_trayslightly off topic but is orforglipron a peptide at all#oral-glp1 · 2025-06-27evidence_or_notSNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2025-06-27mhra_unlicensedchanged my mind on the plain water rule after reading how SNAC works, its not a formality#oral-glp1 · 2025-06-27half_life_halchanged my mind on the plain water rule after reading how SNAC works, its not a formality#oral-glp1 · 2025-06-28half_life_halthe non peptide orals are the interesting part of this channel now, not oral semaglutide, happy to be corrected#oral-glp1 · 2025-06-28baseline_driftPIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses, i think#oral-glp1 · 2025-06-28baseline_driftis the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2025-06-28cold_pack_carlaSNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2025-06-28bea_reconstitutesSNAC does the work#oral-glp1 · 2025-06-28coelution_caiis the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2025-06-29vialkeeperSNAC does the work#oral-glp1 · 2025-06-29vialkeeperchanged my mind on the plain water rule after reading how SNAC works, its not a formality#oral-glp1 · 2025-06-29typosquat_tayis orforglipron a peptide at all#oral-glp1 · 2025-07-01tail_factorfollow up changed my mind on the plain water rule after reading how SNAC works, its not a formality#oral-glp1 · 2025-07-01tokyo_taperPIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses, from memory#oral-glp1 · 2025-07-03seizure_letterorforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ, ill dig out the number#oral-glp1 · 2025-07-07seizure_letteris orforglipron a peptide at all#oral-glp1 · 2025-07-07seizure_letterSNAC does the work#oral-glp1 · 2025-07-07seizure_letteris the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2025-07-07two_four_ceilingchanged my mind on the plain water rule after reading how SNAC works, its not a formality#oral-glp1 · 2025-07-07two_four_ceilingdoes SNAC do anything other than get it through the stomach#oral-glp1 · 2025-07-07seizure_letterwent back to injecting#oral-glp1 · 2025-07-07nhs_pathway_nellSNAC does the work#oral-glp1 · 2025-07-13reta_resting_hrorforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ#oral-glp1 · 2025-07-13nhs_pathway_nellupdate on the earlier thing changed my mind on the plain water rule after reading how SNAC works, its not a formality#oral-glp1 · 2025-07-13alt_ast_alidoes SNAC do anything other than get it through the stomach#oral-glp1 · 2025-07-13oasis_olaSNAC raises the local pH and protects it long enough to cross, thats its whole job, i have it written down somewhere#oral-glp1 · 2025-07-13first_and_last_foursorry to jump in the non peptide orals are the interesting part of this channel now, not oral semaglutide, from memory#oral-glp1 · 2025-07-14hair_month_fourPIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses#oral-glp1 · 2025-07-14reta_resting_hrSNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2025-07-14power_through_noorforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ#oral-glp1 · 2025-07-14hair_month_fourdoes SNAC do anything other than get it through the stomach#oral-glp1 · 2025-07-14reship_ritaPIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses#oral-glp1 · 2025-07-20