Topic
Oral GLP-1s
Page 12 of 13 — Oral semaglutide with SNAC, roughly one percent bioavailability, the fasting and plain-water rules, and the non-peptide orals…
Messages — page 12 of 13
maintenance_moSNAC does the work#oral-glp1 · 2026-06-06first_and_last_fourorforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ#oral-glp1 · 2026-06-06satiety_sigis the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2026-06-06snac_and_waterSNAC does the work#oral-glp1 · 2026-06-08monoisotopicthe non peptide orals are the interesting part of this channel now, not oral semaglutide#oral-glp1 · 2026-06-08batch_banditchanged my mind on the plain water rule after reading how SNAC works, its not a formality, i could be wrong#oral-glp1 · 2026-06-08brisbane_bacSNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2026-06-09elm_escalatesPIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses#oral-glp1 · 2026-06-09elm_escalatesorforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ#oral-glp1 · 2026-06-09protein_floordoes SNAC do anything other than get it through the stomach#oral-glp1 · 2026-06-09ghent_gradientis orforglipron a peptide at all#oral-glp1 · 2026-06-09mcg_not_mgthe non peptide orals are the interesting part of this channel now, not oral semaglutide, ymmv#oral-glp1 · 2026-06-10blind_submitSNAC does the work#oral-glp1 · 2026-06-10triumph_watchthe non peptide orals are the interesting part of this channel now, not oral semaglutide#oral-glp1 · 2026-06-11orfor_watchSNAC does the work#oral-glp1 · 2026-06-11igf_one_ivySNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2026-06-12igf_one_ivychanged my mind on the plain water rule after reading how SNAC works, its not a formality#oral-glp1 · 2026-06-12bolus_boSNAC does the work#oral-glp1 · 2026-06-15oli_oralschanged my mind on the plain water rule after reading how SNAC works, its not a formality#oral-glp1 · 2026-06-15orfor_watchwhile im here PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses, n of 1 obviously#oral-glp1 · 2026-06-15acer_asksthe non peptide orals are the interesting part of this channel now, not oral semaglutide#oral-glp1 · 2026-06-15dublin_dosefor the archive SNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2026-06-15tesa_tessorforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ#oral-glp1 · 2026-06-15hazel_holdsis the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2026-06-15acer_asksdoes SNAC do anything other than get it through the stomach#oral-glp1 · 2026-06-15bolus_boplain water only#oral-glp1 · 2026-06-17warsaw_vialthe non peptide orals are the interesting part of this channel now, not oral semaglutide, your mileage will differ#oral-glp1 · 2026-06-17warsaw_vialorforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ#oral-glp1 · 2026-06-17warsaw_vialorforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ#oral-glp1 · 2026-06-17bolus_book so changed my mind on the plain water rule after reading how SNAC works, its not a formality#oral-glp1 · 2026-06-17chlorhexSNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2026-06-17u100_patPIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses#oral-glp1 · 2026-06-18pinch_not_stretchSNAC does the work#oral-glp1 · 2026-06-18tablet_tamabout one percent#oral-glp1 · 2026-06-18month_six_meSNAC does the work#oral-glp1 · 2026-06-19split_the_costSNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2026-06-19invoice_mismatchis orforglipron a peptide at all#oral-glp1 · 2026-06-20amsterdam_aliquotSNAC does the work#oral-glp1 · 2026-06-20amsterdam_aliquotunrelated but orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ#oral-glp1 · 2026-06-20verify_or_dontSNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2026-06-22split_shipmentorforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ the oral mg number is…#oral-glp1 · 2026-06-22gorse_gainsis the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2026-06-22gorse_gainsis orforglipron a peptide at all#oral-glp1 · 2026-06-22tare_weightPIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses#oral-glp1 · 2026-06-22non_scale_winchanged my mind on the plain water rule after reading how SNAC works, its not a formality#oral-glp1 · 2026-06-22non_scale_wincoming back to this does SNAC do anything other than get it through the stomach#oral-glp1 · 2026-06-22closer_not_simpleris the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2026-06-23abdo_two_inchPIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses#oral-glp1 · 2026-06-23fake_trackingSNAC does the work#oral-glp1 · 2026-06-23abdo_two_inchquick one the non peptide orals are the interesting part of this channel now, not oral semaglutide the non peptide orals are…#oral-glp1 · 2026-06-23orfor_watchchanged my mind on the plain water rule after reading how SNAC works, its not a formality#oral-glp1 · 2026-06-24drawup_deeright so is orforglipron a peptide at all#oral-glp1 · 2026-06-24spreadsheet_stuthe non peptide orals are the interesting part of this channel now, not oral semaglutide#oral-glp1 · 2026-06-25apob_over_ldlswitched from injectable to oral, lost some of the effect, switched back after 16 months, thats just me#oral-glp1 · 2026-06-28ivy_injectsis orforglipron a peptide at all#oral-glp1 · 2026-06-28ivy_injectsSNAC does the work#oral-glp1 · 2026-06-28night_pinPIONEER not OASIS#oral-glp1 · 2026-06-28unsolicited_dmPIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses#oral-glp1 · 2026-06-29unsolicited_dmtea also does not count, in case anyone was hoping#oral-glp1 · 2026-06-29ferrous_ashdoes SNAC do anything other than get it through the stomach#oral-glp1 · 2026-06-29