Topic
Tirzepatide
Dual GIP/GLP-1 agonism, the SURMOUNT and SURPASS trials, the 2.5 to 15mg ladder, and the argument about whether anyone needs the top of it.
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2024-01first seen
2026-06last seen
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cold_chain_cmdrlow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom#retatrutide · 2024-01-20noct.titratecoming off semaglutide, is there a conversion or do i restart at 2.5#tirzepatide · 2024-01-22tarpit_tamdid the phase 2 result actually come in higher than the tirzepatide numbers#retatrutide · 2024-03-15week_three_wallGI was about the same as tirzepatide for me, the difference was how fast it arrived, i could be wrong#retatrutide · 2024-03-15quiet.hourswhile im here is the GI worse than tirzepatide or about the same#retatrutide · 2024-03-22LC_MS_Lenadoes switching from semaglutide need a gap or do you just start#tirzepatide · 2024-03-30chlorhexdid the phase 2 result actually come in higher than the tirzepatide numbers#retatrutide · 2024-04-06batch_banditlow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom#retatrutide · 2024-04-19vial_ledgeris the GI worse than tirzepatide or about the same#retatrutide · 2024-04-22cold_chain_cmdrdid the phase 2 result actually come in higher than the tirzepatide numbers#retatrutide · 2024-04-23cold_chain_cmdris the GI worse than tirzepatide or about the same#retatrutide · 2024-05-19gradient_gregappetite suppression at 7.5 was stronger than my tirzepatide experience at a comparable point#retatrutide · 2024-05-25retention_timesorry to jump in tirzepatide is about 4813.5 Da, so 2+ is near 2407.8 and 3+ near 1605.5#hplc-massspec · 2024-05-25apob_over_ldlis the GI worse than tirzepatide or about the same#retatrutide · 2024-05-27food_noise_offcoming back to this is the GI worse than tirzepatide or about the same#retatrutide · 2024-05-28HPLC_HankGI was about the same as tirzepatide for me, the difference was how fast it arrived#retatrutide · 2024-05-28ferrous_ashlow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom#retatrutide · 2024-06-02ferrous_ashok so how do you celebrate this without it being about food#wins · 2024-06-02chlorhexdown 88 and the scale hasnt moved in a fortnight, do i still get to call it a win#wins · 2024-06-02u100_patappetite suppression at 0.25 was stronger than my tirzepatide experience at a comparable point, we shall see#retatrutide · 2024-06-08retention_timeis the GI worse than tirzepatide or about the same#retatrutide · 2024-06-08tenpenceSURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted, someone check my working#tirzepatide · 2024-06-09seven_five_sweetdid the phase 2 result actually come in higher than the tirzepatide numbers#retatrutide · 2024-06-16two_four_ceilingseven days ish#semaglutide · 2024-06-17nhs_pathway_nellGI was about the same as tirzepatide for me, the difference was how fast it arrived#retatrutide · 2024-06-25nhs_pathway_nellappetite suppression at 0.5 was stronger than my tirzepatide experience at a comparable point#retatrutide · 2024-06-26two_four_ceilinglow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom#retatrutide · 2024-07-01mg_per_mlappetite suppression at 0.25 was stronger than my tirzepatide experience at a comparable point#retatrutide · 2024-07-03mg_per_mlGI was about the same as tirzepatide for me, the difference was how fast it arrived#retatrutide · 2024-07-03u100_patlow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom#retatrutide · 2024-07-06food_noise_offdid the phase 2 result actually come in higher than the tirzepatide numbers#retatrutide · 2024-07-07hair_month_fourthe 15 vial in 5ml gives 2mg/ml which puts 1 on 10 units, nice round numbers, ill dig out the number#tirzepatide · 2024-07-15lot_number_loufollow up appetite suppression at 1.7 was stronger than my tirzepatide experience at a comparable point#retatrutide · 2024-07-17chlorhexappetite suppression at 1.7 was stronger than my tirzepatide experience at a comparable point#retatrutide · 2024-07-18two_four_ceilinglow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom#retatrutide · 2024-07-18gradient_greglow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom#retatrutide · 2024-07-19reta_resting_hrdid the phase 2 result actually come in higher than the tirzepatide numbers#retatrutide · 2024-07-20peak_splitSURMOUNT-OSA — tirzepatide in obstructive sleep apnoea with obesity#tirzepatide · 2024-07-22VialBotarchive lookup: `AHI` mentioned in 41 lines, 9 of them with attached sleep study data. #tirzepatide #wins #bloodwork#tirzepatide · 2024-07-22surpass_twoupdate from 9 months ago: a1c down, apob unchanged, and i am genuinely annoyed about the apob#bloodwork · 2024-07-29karl_fischerlow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom#retatrutide · 2024-08-02protein_floorupdate on the earlier thing is the GI worse than tirzepatide or about the same#retatrutide · 2024-08-02cold_chain_cmdrGI was about the same as tirzepatide for me, the difference was how fast it arrived#retatrutide · 2024-08-02first_and_last_fourslightly off topic but did the phase 2 result actually come in higher than the tirzepatide numbers#retatrutide · 2024-08-04first_and_last_fouris the GI worse than tirzepatide or about the same#retatrutide · 2024-08-04plateau_penif i hold at 12 indefinitely am i losing anything#dosing-titration · 2024-08-08lot_number_louplateaus move#semaglutide · 2024-08-14cold_chain_cmdrGI was about the same as tirzepatide for me, the difference was how fast it arrived#retatrutide · 2024-08-18eight_mmappetite suppression at 7.5 was stronger than my tirzepatide experience at a comparable point, i could be wrong#retatrutide · 2024-08-24triple_ag_tomGI was about the same as tirzepatide for me, the difference was how fast it arrived, not advice obviously#retatrutide · 2024-08-26a1c_lagdid the phase 2 result actually come in higher than the tirzepatide numbers#retatrutide · 2024-08-27u100_patis the GI worse than tirzepatide or about the same#retatrutide · 2024-08-27apob_over_ldlright so appetite suppression at 15 was stronger than my tirzepatide experience at a comparable point, your mileage will differ#retatrutide · 2024-08-29non_scale_winappetite suppression at 5 was stronger than my tirzepatide experience at a comparable point#retatrutide · 2024-08-31triumph_watchlow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom#retatrutide · 2024-09-04HPLC_Hankit does appear in the trial tables at low rates, and it tracks with how much weight came off#side-effects · 2024-09-04triumph_watchis the GI worse than tirzepatide or about the same#retatrutide · 2024-09-05slow.tapersorry to jump in did the phase 2 result actually come in higher than the tirzepatide numbers#retatrutide · 2024-09-05gip_glp_gilchanged my mind about needing 15, i was chasing a number rather than an outcome#tirzepatide · 2024-09-06ring_size_downfollow up 40 units of a 10 solution is a lot of volume and i check that one twice every single time#tirzepatide · 2024-09-06