Topic
Tirzepatide
Page 13 of 15 — Dual GIP/GLP-1 agonism, the SURMOUNT and SURPASS trials, the 2.5 to 15mg ladder, and the argument about whether anyone needs the…
Messages — page 13 of 15
olive_orderscoming off semaglutide, is there a conversion or do i restart at 2.5#tirzepatide · 2026-04-03lead_time_larssame plateau here#tirzepatide · 2026-04-03no_appetite_niaGI was about the same as tirzepatide for me, the difference was how fast it arrived#retatrutide · 2026-04-05triumph_watchdid the phase 2 result actually come in higher than the tirzepatide numbers#retatrutide · 2026-04-05HPLC_Hanktirzepatide is about 4813.5 Da, so 2+ is near 2407.8 and 3+ near 1605.5#hplc-massspec · 2026-04-05nettle_notesGI was about the same as tirzepatide for me, the difference was how fast it arrived, we shall see#retatrutide · 2026-04-06kev_measuresdid the phase 2 result actually come in higher than the tirzepatide numbers#retatrutide · 2026-04-06blank_runSURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up#tirzepatide · 2026-04-07egfr_edGI was about the same as tirzepatide for me, the difference was how fast it arrived#retatrutide · 2026-04-07wrong_networkafter a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice#dosing-titration · 2026-04-07cat_on_the_trayGI was about the same as tirzepatide for me, the difference was how fast it arrived, for what its worth#retatrutide · 2026-04-08bea_reconstitutesis the GI worse than tirzepatide or about the same#retatrutide · 2026-04-08relabel_watchappetite suppression at 7.5 was stronger than my tirzepatide experience at a comparable point, we shall see#retatrutide · 2026-04-08non_scale_winlow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom TRIUMPH is the phase 3…#retatrutide · 2026-04-10juniper_joinstirzepatide is about 4813.5 Da, so 2+ is near 2407.8 and 3+ near 1605.5#hplc-massspec · 2026-04-11gip_glp_gilappetite suppression at 15 was stronger than my tirzepatide experience at a comparable point#retatrutide · 2026-04-12provincial_patGI was about the same as tirzepatide for me, the difference was how fast it arrived#retatrutide · 2026-04-12combo_caidid the phase 2 result actually come in higher than the tirzepatide numbers#retatrutide · 2026-04-13bad_batch_not_scamSURMOUNT-OSA reported roughly what i got, which surprised me, i had assumed the trial people all did better, ask me again in a…#wins · 2026-04-14rotate_the_siteis the GI worse than tirzepatide or about the same energy expenditure isnt something i could feel, though my sleep tracker…#retatrutide · 2026-04-15turnaround_tamlow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom#retatrutide · 2026-04-15chlorhexis SURMOUNT-OSA the sleep apnoea one#tirzepatide · 2026-04-16chlorhexlow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom, thats just me#retatrutide · 2026-04-16nhs_pathway_nellGI was about the same as tirzepatide for me, the difference was how fast it arrived, i could be wrong#retatrutide · 2026-04-16sorrel_sendsappetite suppression at 1 was stronger than my tirzepatide experience at a comparable point#retatrutide · 2026-04-16triumph_watchgenuine question is the GI worse than tirzepatide or about the same#retatrutide · 2026-04-16eight_mmi argued the sweet spot was nonsense and then spent 3 months at 7.5 not needing more#tirzepatide · 2026-04-17ruo_onlyim at 2.4 and thinking about 2.5, did anyone gain anything from that step#tirzepatide · 2026-04-17gus_chartsupdate from 2 months ago: still at maintenance, still boring, which was always the goal#maintenance · 2026-04-17two_lifts_a_weekthe switch felt like a step down at first and then caught up around week 28#tirzepatide · 2026-04-18septum_salis the sweet spot argument about effect or about side effects#tirzepatide · 2026-04-19comment_fatigueappetite suppression at 2.4 was stronger than my tirzepatide experience at a comparable point#retatrutide · 2026-04-19pin29gcoming back after 10 months of maintenance, is anyone interested in the numbers#maintenance · 2026-04-20tare_weightmonths not weeks#wins · 2026-04-21otto_swirlsmy wedding ring fits again after 14 months, does anyone else measure things that arent weight#wins · 2026-04-21power_through_no15 is the top#tirzepatide · 2026-04-22thirty_min_waitis the GI worse than tirzepatide or about the same#retatrutide · 2026-04-22ghent_gradienttirzepatide is about 4813.5 Da, so 2+ is near 2407.8 and 3+ near 1605.5#hplc-massspec · 2026-04-22pbs_pipappetite suppression at 2.4 was stronger than my tirzepatide experience at a comparable point#retatrutide · 2026-04-23mg_per_mlGI was about the same as tirzepatide for me, the difference was how fast it arrived, n of 1 obviously#retatrutide · 2026-04-23batch_bandittirzepatide is about 4813.5 Da, so 2+ is near 2407.8 and 3+ near 1605.5, happy to be corrected#hplc-massspec · 2026-04-23warsaw_vialGI was about the same as tirzepatide for me, the difference was how fast it arrived#retatrutide · 2026-04-24iris_importshoma-ir is fasting glucose times fasting insulin over a constant. the constant differs by unit system, n of 1 obviously#bloodwork · 2026-04-24two_lifts_a_weekdid anyone drop the dose for maintenance or just stay where they were#maintenance · 2026-04-24triple_ag_tomdid the phase 2 result actually come in higher than the tirzepatide numbers#retatrutide · 2026-04-25marrow.modGI was about the same as tirzepatide for me, the difference was how fast it arrived#retatrutide · 2026-04-26clove_chartssorry to jump in low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom#retatrutide · 2026-04-26impersonator_ipdid the phase 2 result actually come in higher than the tirzepatide numbers#retatrutide · 2026-04-26lot_number_louis the GI worse than tirzepatide or about the same#retatrutide · 2026-04-26travel_coolerdid the phase 2 result actually come in higher than the tirzepatide numbers#retatrutide · 2026-04-27rowan_readstirzepatide is about 4813.5 Da, so 2+ is near 2407.8 and 3+ near 1605.5#hplc-massspec · 2026-04-28rotate_the_siteappetite suppression at 2.4 was stronger than my tirzepatide experience at a comparable point, thats one data point#retatrutide · 2026-04-30rotate_the_sitedid the phase 2 result actually come in higher than the tirzepatide numbers#retatrutide · 2026-04-30LC_MS_Lenatirzepatide is about 4813.5 Da, so 2+ is near 2407.8 and 3+ near 1605.5#hplc-massspec · 2026-04-30new_here_natjoined a couple of days ago. is the 20% figure for tirz a real trial number or a marketing number#tirzepatide · 2026-05-02vial_ledgerSURMOUNT-1 — tirzepatide once weekly in adults with obesity#tirzepatide · 2026-05-02new_here_natso tirz just wins#tirzepatide · 2026-05-02new_here_natcoming back up the log — when you said tirz wins on that endpoint, is there a trial where sema wins#tirzepatide · 2026-05-02tail_factornot at matched top doses on weight, no. against sema 1mg in SURPASS-2 tirz won, but 1mg is a diabetes dose, not the 2.4…#tirzepatide · 2026-05-02gradient_gregappetite suppression at 15 was stronger than my tirzepatide experience at a comparable point#retatrutide · 2026-05-02